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Chloroquine In Cancer Therapy A Double-edged Sword Of Autophagy


Keywords: Autophagy, cancer, ATG, ULK inhibitor, Vps34 inhibitor, mammalian target of …. Chloroquine (CQ) is an anti-malarial drug, and is also known as an inhibitor of autophagy. Cancer Res. Jun 14, 2019 · Based on this knowledge, in vivo studies have started to employ autophagy inhibitors, such as inhibitors of the lysosomal protease and anti-malaric drugs, Chloroquine (CQ) or Hydroxichloroquine (HCQ), to treat cancer, more often in combination with chemotherapies able to induce autophagy [17,18,19] In normal cells, autophagy plays an important role in regulating the homeostatic balance, whereas in cancer cells, autophagy is a “double-edged sword” [ 27, 28 ]. Treatment of colon cancer cells with butyrate inhibited cell proliferation, promoted apoptosis in 79% of cells through the activation of caspase-3 and the degradation of PARP Jun 28, 2019 · On the other hand, proliferation of BC cells was significantly inhibited by JQ1 treatment. Aug 23, 2017 · Chloroquine has been reported to act as an effective agent that inhibits autophagy by interfering with chloroquine in cancer therapy a double-edged sword of autophagy the degradative functions of lysosomes, resulting in the accumulation of damaged autolysosomes. The administration of the autophagy inhibitor chloroquine significantly increased the expression of proapoptotic genes (Trp53, Bax, Bak1, Pmaip1, Bcl2l11, Cdkn1a, and Cdkn1b) and DNA fragmentation in the frontal brain region of olanzapine-exposed animals..Autophagy is a homeostatic, catabolic degradation process whereby cellular proteins and organelles are engulfedbyautophagosomes,digestedinlysosomes,andrecycledtosustaincellularmetabolism.Autophagy has dual roles in cancer, acting as both a tumor suppressor by preventing the accumulation of damaged. 29 Aits et al. in the present study, we investigated the effects of CQ and HCQ on cell growth of bladder cancer with emphasis on autophagy inhibition and apoptosis induction in vitro.The results showed that CQ and HCQ inhibited the proliferation of multiple human bladder cell lines. Kimura T, Takabatake Y, Takahashi A and Isaka Y: Chloroquine in cancer therapy: A double-edged sword of autophagy. The chloroquine in cancer therapy a double-edged sword of autophagy inhibition of autophagy by chloroquine may lead to accelerated tumor cell death, reduced chemoresistance and increased radiosensitivity (3) Mitophagy is a double-edged sword. Apr 14, 2016 · Autophagy in dental tissues: a double-edged sword and during local anesthetic treatment. Dec 17, 2014 · Autophagy is a dynamic process, consisting of initiation, nucleation, elongation and maturation. Once thought to be merely a recycling process, autophagy is now recognized as a complex pathway with a plethora of crosstalks with cellular and molecular signaling.Autophagy is a double-edged sword in cancer. Debnath J. However, blocking autophagy with chloroquine enhances the anticancer effect of sunitinib [24]. 2 Al-Bari MA: Chloroquine analogues in drug discovery: New directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases Chloroquine (CQ), an autophagy inhibitor, has been demonstrated to increase the efficacy of chemotherapy in treating several solid tumors, such as hepatocellular carcinoma, breast cancer, and hypopharyngeal carcinoma.16–18 Recent studies on drug resistance mechanisms indicate that the antitumor-augmenting efficacy of CQ is largely due to its autophagy-inhibiting effect.19,20 In contrast, …. New Use for Old Drugs? According to current research, autophagy inhib-ition has been applied to a variety of cancer therapies, such as glioma, myeloma, breast cancer, rectal cancer, and prostate cancer [6]. As a “double-edged sword” in cancer, the regulatory mechanism of autophagy in cancer is complicated, but the observations about specific molecular markers of autophagy have attracted great attention in terms of current anticancer …. Autophagy plays a crucial role in cancer cell survival and the inhibition of autophagy is attracting attention as an emerging strategy for the treatment of cancer.

Allergy Ativan Chloroquine


In the present study, we evaluated the effects of everolimus alone or in combination with chloroquine on renal …. (Clin Cancer Res 2009;15(17):5308–16) The Double-Edged Sword of Autophagy Modulation in Cancer | Clinical Cancer Research. Chronic inhibition of autophagy or autophagy deficiency promotes cancer, due to instability of the genome and defective cell growth and as a result of cell stress. In particular, the autophagy inhibitors chloroquine and hydroxychloroquine, commonly used antimalarial drugs, are currently being investigated in phase I and phase II trials in patients with glioblastoma and myeloma. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy The use of chloroquine in combination with other chemo-therapeutic reagents may enhance cancer treatment (8, 29), but normal cells also use autophagy to maintain homeostasis, Cited by: 387 Publish Year: 2013 Author: Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, Yoshitaka Isaka Chloroquine in Cancer Therapy: A Double-Edged Sword of https://www.researchgate.net/publication/234048306 Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy Article · Literature Review (PDF Available) in Cancer Research 73(1):3-7 · January 2013 with 477 Reads How we measure 'reads'. “But more importantly, we also found a. in cancer therapy. Currently, a number of small molecules that inhibit autophagy initiation (e.g., ULK kinase inhibitors),. On one hand, autophagy plays an antitumor role, on the other hand. In addition, autophagy serves to maintain cellular homeostasis by enriching nutrient pools. prostate cancer cells PC3 and LNCaP, and breast cancer cells MCF7 sho ws that autophagy acts as a surv ival mechanism in hypoxic tumor cells. On the other side, anticancer therapy can stimulate autophagy pathways that mediate ACD (8) Dec 19, 2017 · Dual role of autophagy in hallmarks of cancer. Autophagy and metastasis: another double-edged sword Aug 02, 2016 · Autophagy plays a crucial role in cancer cell survival and the inhibition of autophagy is attracting attention as an emerging strategy for the treatment of cancer. Recently, modulating autophagy by pharmacological agents has. Autophagy, especially under hypoxia, permits activation of transcription factor STAT3, leading to the expression and secretion of cytokines such as IL‐10, and a number of other factors with immunosuppressive effects that help cancer cells escape multiple components of the immune system. Recently, modulating autophagy by pharmacological agents has become an attractive strategy to treat cancer. Li et al .. Bergenstock MK, Murphy M. Debnath J. Therefore, chloroquine may potentially be an effective anticancer drug in clinical oncology. The regulation network of autophagy that influences tumor progression and resistance to therapy depends on the cell/tissue types and the stages of tumor, thereby inhibiting or promoting tumor formation and treatment resistance (Fig. Autophagy is a homeostatic, catabolic degradation process whereby cellular proteins and organelles are engulfedbyautophagosomes,digestedinlysosomes,andrecycledtosustaincellularmetabolism.Autophagy has dual roles in cancer, acting as both a tumor suppressor by preventing the accumulation of damaged. Although autophagy acts as a “double-edged sword” in tumorigenesis , autophagy acts more as a cytoprotective mechanism in tumor therapy Jun 24, 2017 · Autophagy, a self-degradative system, universally chloroquine in cancer therapy a double-edged sword of autophagy arises during the treatment of sensitive and MDR cancer. Autophagy Blockade via Chloroquine (CQ) or Hydroxychloroquine (HCQ) Enhances the Efficacy of RAS–MEK–ERK Inhibition in KRAS-Driven Cancers. Autophagy in tumor suppression and cancer therapy. 73:3–7. Apr 13, 2009 · In 2004, Tsujimoto and coworkers 28 reported that, in response to etoposide or staurosporine, mouse embryonic fibroblasts undergo cell death accompanied by autophagy, which can be reduced by knockdown of Agt5 or Beclin1. Keywords:ATG4, ATG4B, autophagy, cancer, autophagy inhibition, targeting. However, increased induction of autophagy can become a mechanism which allows tumor cells to survive …. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer It is like a double-edged sword that can play either a protective or destructive role in cancer, by pro-survival chloroquine, etc.) are reported in pre-clinical and clinical study. Therefore, this review tries to fill this gap. This implies that if we understand when autophagy is a good thing and when it's a bad thing, it will be feasible to improve treatment or prevention of these diseases by manipulating. Oct 01, 2014 · Therefore, chloroquine may potentially be an effective anticancer drug in clinical oncology. Importantly, they demonstrated that autophagy blockade via chloroquine (CQ) or hydroxychloroquine (HCQ) enhanced the efficacy chloroquine in cancer therapy a double-edged sword of autophagy of MEK–ERK inhibition in various preclinical models of KRAS-driven cancers, providing a rational basis for future clinical evaluation of this combination therapy. Chloroquine (CQ) is an anti-malarial drug, and is also known as an inhibitor of autophagy (A) P4, the viral capsid protein of caulimoviruses, is a bona fide cargo of plant NBR1, thus enabling clearance of viral particles by autophagy [8]. Jul 14, 2016 · Inhibiting the induction of autophagy by chloroquine or siRNA in bacterial cancer therapy dose- and time-dependently promoted cell death. 2 and then switched to MAS buffer before permeabilization with PMP and OCR ….

Malaria medication hydroxychloroquine, chloroquine a cancer therapy double-edged in of sword autophagy

Cited by: 387 Publish Year: 2013 Author: Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, Yoshitaka Isaka [PDF] Chloroquine in Cancer Therapy: A Double-Edged Sword of https://cancerres.aacrjournals.org/content/canres/73/1/3.full.pdf cesses of autophagy is a more preferable approach in cancer therapy, however, and is now under investigation (28). Introduction Chloroquine (CQ), a 4-aminoquinoline compound, has long been prescribed for the treatment of malaria- (1), autoim mune disorders(2) and viral infections (3). It has also been demonstrated that chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy inhibition , and the potential side effects of chloroquine therapy have also been cautiously discussed , . Autophagy plays a crucial role in cancer cell survival and the inhibition of autophagy is attracting attention as an emerging strategy for the treatment of cancer. Inhibition of KRAS, MEK, or ERK induces autophagic flux in KRAS-driven cancer cells via metabolic rewiring and activation of the AMPK–ULK1 pathway Regulation of autophagy by short chain fatty acids. As such, autophagy is tumor suppressive Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment Liang Qin,1,* Tianyuan Xu,1,* Leilei Xia,1 Xianjin Wang,1 Xiang Zhang,1 Xiaohua Zhang,1 Zhaowei Zhu,1 Shan Zhong,1 Chuandong Wang,2 Zhoujun Shen1 1Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 2Key Laboratory of Stem Cell Biology. As a “double-edged sword” in cancer, the regulatory mechanism of autophagy in cancer is complicated, but the observations about specific molecular markers of autophagy have attracted great attention in terms of current anticancer …. Exploitation of the functional autophagy status in tumors and pharmacologic autophagy modulation for cancer treatment and prevention presents novel opportunities in cancer management A major problem with the clinical trials is how to identify patients who are most likely to benefit from autophagy-based cancer therapy. Cited by: 387 Publish Year: 2013 Author: Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, Yoshitaka Isaka Chloroquine in cancer therapy: a double-edged sword of https://www.ncbi.nlm.nih.gov/pubmed/23288916 Jan 01, 2013 · Chloroquine in cancer therapy: a double-edged sword of autophagy. 30 found that …. Introduction Chloroquine (CQ), a 4-aminoquinoline compound, has long been prescribed for the treatment of malaria- (1), autoim mune disorders(2) and viral infections (3). Recently, it has been found that CQ induces cancer cell death through the inhibition of autophagy; however, the underlying mechanism is …. Abstract: Aside from its function in cellular homeostasis, autophagy enables cells to dispose of damaged cellular components and to recycle metabolites in response to cellular stress Kimura T, Takabatake Y, Takahashi A and Isaka Y: Chloroquine in cancer therapy: A double-edged sword of autophagy. Autophagy Blockade via Chloroquine (CQ) or Hydroxychloroquine (HCQ) Enhances the Efficacy of RAS–MEK–ERK Inhibition chloroquine in cancer therapy a double-edged sword of autophagy in KRAS-Driven Cancers. Bergenstock MK, Murphy M. Figure 1. Understanding the role of autophagy in cancer treatment is critical, because many anticancer therapies have been shown to activate. Jan 24, 2018 · Radiation therapy is a cytoprotective autophagy inducer in prostate cancer cells , it was also reported that incubation of LNCaP cells in serum-free medium lead to a pro-death autophagy process . Cancer Res. Later, as a tumor grows, cancer cells may need autophagy to survive nutrient-limiting and low-oxygen conditions, especially in the internal region of the tumor that is poorly vascularized ( 12 ) Apr 13, 2009 · Autophagy—A double‐edged sword in oncology However, less has been reported about interactions of autophagy manipulation to the outcome of cancer therapy and tumour growth.

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